|
KMID : 0191120110260080991
|
|
Journal of Korean Medical Science
2011 Volume.26 No. 8 p.991 ~ p.995
|
|
|
XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample
|
|
Ryu Ri-A
Tae Kyung
Min Hyun-Jung
Jeong Jin-Hyeok
Cho Seok-Hyun
Lee Seung-Hwan
Ahn You-Hern
|
|
|
Abstract
|
|
|
|
Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
|
|
|
KEYWORD
|
|
|
Polymorphisms, XRCC1, SNP, Papillary Thyroid Carcinoma, Susceptibility
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|